- Prepare grill for medium heat.
- Mix oregano, sesame seeds, cumin, salt, and red pepper flakes in a small bowl to combine; set spice mixture aside.
- Beginning and ending with salmon, thread salmon and folded lemon slices onto 8 pairs of parallel skewers to make 8 kabobs total.
- Brush with oil and season with reserved spice mixture.
- Grill, turning occasionally, until fish is opaque throughout, 5-8 minutes.